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Potential Mechanisms of THC on Neuroprotection and Repair Antioxidation THC expedites the clearance of free radicals within the body by activating a suite of antioxidant enzymes, including superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), and glutathione S-transferase (GST), thereby reinforcing the stability of the brains antioxidant enzyme system [5]

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Neurology 62:17581765 Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gascon S, Hatzios SK, Kagan VE, Noel K, Jiang X, Linkermann A, Murphy ME, Overholtzer M, Oyagi A, Pagnussat GC, Park J, Ran Q, Rosenfeld CS, Salnikow K, Tang D, Torti FM, Torti SV, Toyokuni S, Woerpel KA, Zhang DD (2017) Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease

In senescent ECs, increased LD accumulation was linked to elevated expressions of proinflammatory cytokines [91]