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Discovery of -carboline derivatives as a highly potent cardioprotectant against myocardial ischemia-reperfusion injury

SparksJABarbhaiyaMTedeschiSKLeatherwoodCLTabungFKSpeyerCBet al

Ko T.-P

The New York Times

Moreover, as mitochondria play a central strategic role in the activation and mode of cell death, mitochondrial GSH has been shown to critically regulate the level of sensitization to secondary hits that induce mitochondrial membrane permeabilization and release of proteins confined in the intermembrane space that once in the cytosol engage the molecular machinery of cell death

Notably, alterations in the binding of AP-1 family members, such as FRA-2 and JUND, were closely linked to increased DNA methylation, suggesting that mutant HTT may disrupt normal transcriptional regulation (212)