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LDN is also an antagonist of non-opioid receptors, called Toll-Like Receptors (TLR-4 and TLR-9), which reduce cytokines and other inflammatory signal molecules

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Methods: Patients eligible for PEDFIC 1 (NCT03566238) and PEDFIC 2 (NCT03659916) had elevated serum bile acids and significant pruritus at screening