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Therapeutic targeting of STING-TBK1-IRF3 signalling ameliorates chronic stress induced depression-like behaviours by modulating neuroinflammation and microglia phagocytosis

[DOI] [PubMed] [Google Scholar] 118.Cozzolino M., Carr M.T

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Crucially, mitochondrial metabolism reprogramming is orchestrated by core regulatory pathways (such as the HIF axis, AMPK/mTOR signaling, and sirtuin-mediated deacetylation cascades), which collectively modulate pyruvate dehydrogenase (PDH) activity, ETC efficiency, and anaplerotic flux (56)

O2- can release iron ions under stress conditions from the iron-sulfur of proteins, participating in the Fenton reaction and converting H2O2 to OH (40)