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Semaglutide is a synthetic glucagon-like peptide-1 (GLP-1) receptor agonist developed for the treatment of type 2 diabetes and obesity

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Using recommended dosing conditions for oral semaglutide, mean bioavailability was estimated at approximately 0.8% (0.795% [95% confidence interval 0.7360.864]) (Table 1 of the ESM)

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1 GLP-1R is involved in regulating both insulin and glucagon secretion, and its knockout can impair pancreatic function, thereby affecting the balance of these hormones and glucose homeostasis