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Despite lower efficacy and tolerability shown by nasally administered PYY agonists in early studies, long-acting subcutaneous PYY receptor agonists such as PYY 1875 are undergoing early-phase clinical trials to evaluate their safety and effectiveness as monotherapy or in combination with GLP-1 receptor agonists for the treatment of obesity

Other O -methylationrelated metabolites (M7M11) were also detected in rat liver S9 incubations supplemented with NADPH and SAM (Supplementary Fig

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USA 100 , 29112916 (2003)

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is an obligate intracellular protozoan parasite that causes sleeping sickness in humans in many countries of sub-Saharan Africa