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Elesclomol is widely recognized to induce copper overdose and cell death (139), by acting as a copper ion carrier with a hydrophilic pore in its centre, to which Cu2+ ions can bind easily, facilitating copper entry into cells, thus increasing the intracellular copper concentration (140), and this, in-turn increases ROS levels, triggering oxidative stress (141) and ultimately cell death

familial (D75.0) Sequencing reviewed: underlying condition first when Code first instruction applies No simultaneous assignment of D62 and D50.0 (Excludes1) MS-DRG impact reviewed: D62 as secondary diagnosis = MCC

Adv Gerontol

Rigorous scientific studies and experiments have since been conducted to determine the potential action of AOD 9604 in lipolysis