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Specific gut inflammation (190) and gut hyper-permeability (219) have been identified, and microbe and virus communities may also persist in ME/CFS blood and brain tissue (193)

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In addition, a new role of lytic replication has been described in sustaining the population of latently infected cells that otherwise would be quickly lost by segregation of latent viral episomes as spindle cells divide (Grundhoff and Ganem, 2004)

3.5.2 C-reactive protein (CRP) The degree of raised CRP levels in CSF has been reported to be strongly correlated with the severity of non-motor symptoms in PD patients