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However, further dose-response analysis and adjustment for intake of other vitamin and mineral supplements indicated that all-cause mortality risk was significantly increased by 7% only at a dose of 2,000 IU/day, which is notably higher than the UL for adults (1,100 IU/day of synthetic tocopherol or 1,500 IU/day of natural tocopherol)

Spalletta P, Bernardini G, Bellincampi S, Federici L, Trequattrini G, Ciappi A, et al

Where available, endoscopic data including tissue biopsies were collected

GPX4 uses GSH as substrate to reduce membrane phospholipid hydroperoxide to harmless fatty alcohol (Forcina and Dixon, 2019)

Among smoking-related conditions, chronic obstructive pulmonary disease (COPD) is the most representative example