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Capsid-optimized adenovirus-associated virus 8 vectors was used to deliver the CRISPR-CasRx system to pancreatic cancer in situ tumors and patient-derived tumor xenografts, demonstrating that CasRx accurately and efficiently silenced the expression of Kras G12D mutants in pancreatic ductal adenocarcinoma cells guided by Kras G12D -specific gRNA

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Damage to or a reduction in the function of these cells can lead to insufficient insulin secretion, resulting in diabetes