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Synthetic hormones like Premarin or Provera have a different molecular structure the body metabolizes differently

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10.1038/s41467-024-48637-y 70 LiY.YangJ.LinM.LiuT.LuW.YangY.et al (2025)

The HSPs, in plants, consists an abundant group of low mo1 wt polypeptides with higher molecular weight families [91], where some of them found to function as chaperones minimizing high-temperature stress damage partially denaturing proteins and preventing breakdown or aggregation

doi: 10.3390/children9040462

After three months of treatment, 77% of patients reported significant improvement in pain scores and autonomic symptoms