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Fourteen patients (0.5%: 12 men and 2 women) had elevated serum Hcy in the absence of an associated MTHFR variant: this can be due to a folate trap syndrome or anomalies/mutations in the CBS/MS pathway

Because the body cannot naturally produce B12, it must be obtained from diet or supplementation, unlike many other vitamins

Peripheral administration of GSHee increases the concentrations of GSHee, GSH and cysteine in blood cells, peripheral organs 49,50,51 and cerebrospinal fluid 52 , but not brain tissue 53