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So if we were to inhibit the SLC33A1 transporter, the GSSG would accumulate, and the cancer cells would die. Our work demonstrates that defining how nutrients and metabolites are transported across cellular and organelle membranes reveals fundamental principles of cell biology while uncovering a major class of disease-relevant and therapeutically tractable proteins, Birsoy says

2018;28:92234.e4

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Concurrently, Pax2-driven induction of fibroblast growth factor 8 (FGF8) expression in the isthmic organizer establishes the molecular framework for VM DA progenitor patterning (Ye et al., 2001)