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c-di-GMP turn-over in Clostridium difficile is controlled by a plethora of diguanylate cyclases and phosphodiesterases

10.1021/acs.jpclett.7b00127 371 Linderstrm-LangK

The compound enhances cytotoxic T lymphocyte responses and prevents immunological unresponsiveness

Peptide therapy also contributes to immune health indirectly by reducing systemic inflammation and supporting gut integrity where approximately 70% of your immune system resides

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It will therefore be important to define the epitope specificity and serum neutralization activity in these animal models, and potential T cell mechanisms will need to be excluded before enhanced immunopathology can be attributed to antibody mechanisms