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The temporal progression of AD should also be considered in BBB-targeted drug delivery

Under such conditions, several RTKs including EGFR, ErbB3, Axl, PDGFR, RYK and Met were phosphorylated to some degree (see Mock in Supplementary Fig

The lead candidate 37 (HFI-419) exhibits brain exposure following intravenous administration in rats but was found to be rapidly degraded to the corresponding deacetylated and less active IRAP inhibitor (Mountford et al., 2014)