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Kimura K, Ito M, Amano M, Chihara K, Fukata Y, Nakafuku M, Yamamori B, Feng J, Nakano T, Okawa K, Iwamatsu A, Kaibuchi K

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Some of these aggregates are detected only in specific ALS subtypes (for example, dipeptide aggregates and intranuclear RNA deposits in C90RF72 ALS

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Apoptosis regulatory effector: caspase-1 Caspase-1 is an effector enzyme of pyroptosis, promoting the maturation and secretion of potent pro-inflammatory cytokines such as IL-1 and IL-18 in humans and mice, as well as a form of inflammatory lytic cell death known as pyroptotic cell death. Human caspase-4 and caspase-5, along with their murine homolog caspase-11, mediate the activation of noncanonical inflammasomes