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Unfortunately, the results seen from anti-amyloid (plaque buster) clinical trials have been disappointing [9]

Because of the disappointing results of clinical trials, minimizing homocysteine levels is no longer the primary goal of our recommendations

The MISEV2018 guidelines offer standardized recommendations to improve the rigor and reproducibility of EV studies, which include (i) considerations for EV separation/enrichment, (ii) EV characterization (e.g., size, concentration, morphology, molecular marker, protein content-based EVs, etc.), (iii) EV-associated and EV-excluded biological activities, and (iv) reporting standardsreporting the EV source, isolation, characterization, and experimental design (Thry et al., 2018)

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