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Moreover, we have demonstrated that low picomolar PregS increases [Ca 2+ ]i and CREB phosphorylation and the frequency of spontaneous excitatory post-synaptic currents (Figures 8, 9)

Abstract Nutraceuticals represent promising strategies for preventing, delaying and addressing premature aging of the skin, especially as women advance in years (particularly after 30 years of age, when estrogen levels begin to decline, and remarkably after menopause when estrogen production ceases from the ovaries)