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It consists of a series of enzymatic reactions that convert methionine into essential intermediates for neuronal function

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in fact, for most mutants, enzyme instability is the main mechanism of enzyme deficiency ( Fig

Proc Natl Acad Sci USA (2016) 113:113005

Arya JK, Kumar R, Tripathi SS, Rizvi SI (2022) 3-Bromopyruvate, a caloric restriction mimetic, exerts a mitohormetic effect to provide neuroprotection through activation of autophagy in rats during aging

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