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All individuals with these atypical variants exhibited skin hyperextensibility as seen in individuals with cEDS and clEDS and evidence of tissue fragility as seen in individuals with vEDS demonstrating the importance of gene panel testing

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AI-driven analyses can uncover novel compounds and predict their senescence-modulating properties based on biological data.206 Moreover, systems biology approaches that analyze the complex networks of cellular aging processes could help uncover new targets for senomorphic therapies and optimize their clinical applications.207 Combination Therapies: Synergizing Senolytics and Senomorphics While both senolytics and senomorphics offer promising approaches for targeting cellular senescence, recent research suggests that combining these two therapeutic strategies may enhance their individual benefits, leading to more robust outcomes in promoting healthy aging