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This finding is intriguing because human glutathione synthetase deficiency, a heritable amino acid metabolism disorder, also leads to hyperaccumulation of pyroglutamic acid resulting in high anion gap metabolic acidosis a form of acidosis defined by acid accumulation and low pH of the blood 48

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The varying effects of HbS on infection suggest that its protective role against malaria may be related to controlling P.f hyperparasitemia [21]