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In turn, this disrupts the gut barrier function and may result in acute and chronic inflammatory states (Hine and Loke, 2020)

External stressors like stressful or traumatic incidents, acute infection, and toxic stressors may result in widespread and chronic systemic and even neuroinflammation, driven by a variety of inflammatory molecules in circulation

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It is crucial to note that VAN criteria can vary among studies and may include increases in serum creatinine, decreases in urine output, or the need for renal replacement therapy

DSIPs stability and ability to cross the blood-brain barrier contribute to its potential major therapeutic benefit