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GPX4: The core downstream antioxidant of system X c /GSH/GPX4 axis As the cornerstone of antioxidant defense, GPX4, a phospholipid peroxidation inhibitor, is the only glutathione peroxidase used for intracellular lipid peroxide reduction (Ursini et al., 1982)

Methods A PRISMA-guided systematic review (Figure 1) was performed using PubMed and MEDLINE databases, employing search terms glutathione AND topical AND skin OR dermatology, yielding 446 articles with no time restriction

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Therapeutic Perspectives Targeting Ferroptosis in FRDA The emergence of ferroptosis as a pivotal mechanism in FRDA partially redefines the landscape for therapeutic intervention [105]

Invest Ophthalmol Vis Sci 2008