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ALA may help correct several mechanisms involved in DPN, including sorbitol accumulation, microvascular damage, oxidative stress, and lipid peroxidation [16]

It is regarded as a rich emollient in the cosmetics industry, making it one of the main components, especially in body lotions and full body moisturizers, that can moisturize and give a soft and supple external barrier to even the driest skin (Purnamawati, Indrastuti, Danarti, & Saefudin, 2017)

doi: 10.1016/j.cell.2020.12.025 219 MariniM.NiuY.ZhaoH.MohanA.KoorndykN.KruyerA.et al

A proposed role in ascorbic acid metabolism

10.1111/ejn.13357 [DOI] [PMC free article] [PubMed] [Google Scholar] Lolicato F, Juhola H, Zak A, Postila PA, Saukko A, Rissanen S, Enkavi G, Vattulainen I, Kepczynski M, Rg T, 2020

In addition to improving mitochondrial respiration and electron transport chain activity, -KG replenishes TCA cycle intermediates, which raises the production of ROS (Martnez-Reyes and Chandel, 2020