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Half maximal inhibitory concentration (IC 50 ) values were calculated using a four parameter non-linear regression curve with Graph Pad Prism v8 (GraphPad, La Jolla, CA, USA)

In the test system with hamster S9-mix, NMA, NDMA, and NDELA might all be considered equipotent, but with the relatively higher uncertainty (BMD 100 CI ratio: 15.4) and variability of the NMA data, a final conclusion could not be drawn

No oral or topical therapy has been shown to be efficacious when administered alone, but some evidence supports their use as part of a combination therapy regimen

References Francis GL, et al

TrappoliereMCaligiuriASchmidMBertolaniCFailliPVizzuttiFet al

Nazem, M