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These approaches remain largely investigational and are not widely used in mainstream medicine

In a randomized, placebo-controlled study of 495 patients with intermittent claudication, 2 g/day of propionyl-L-carnitine for 12 months significantly increased maximal walking distance and the distance walked prior to the onset of claudication in patients whose initial maximal walking distance was less than 250 meters (m), but no effect was seen in patients who had an initial maximal walking distance greater than 250 m (65)

Therapeutically, repleting hepatic GSH is rational

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These findings indicated that, after NPs-FM19G11 administration, the metabolic profile of epSPCs from G93A-SOD1 mice at the symptomatic disease stage was more closely regulate that of the control group compared to untreated G93A-SOD1 cells