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Reactions were performed with 0.5 M catechol substrate COMT-S01, 1 M radiolabelled S-adenosyl-L-[methyl- 3 H] methionine (SAM) co-substrate, and recombinant human COMT enzyme

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(2018) Alexandre Defossez, Neil Zeghidour, Nicolas Usunier, Leon Bottou, and Francis Bach

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This is the most common type of hypothyroidism in the developed world It is the result of T-cell mediated auto-reactive cytotoxicity against follicular cells