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OPERA-01: A randomized, open-label, phase 3 study of palazestrant (OP-1250) vs standard-of-care for ER+, HER2- advanced or metastatic breast cancer patients after endocrine therapy and CDK4/6 inhibitors

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This and the fact that we previously established efficient glutarate production employing the LdcC-PatA-PatD-GabT-GabD pathway provided an ideal starting point to establish fermentative production of l-2HG from renewable resources

When cells were grown to about 80% confluence, the culture medium was changed to a fresh medium solution with the following metabolites for 12 h