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Gene-editing therapies aim to correct the genetic defects or pathological processes underlying PD at their source, with the goal of directly intervening in the disease's genetic or molecular etiology, protecting neurons, and halting or delaying disease progression [214]

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Mean visual analog scale scores were 21.0 (standard deviation 18.2, range 0-65) for buffered injections and 27.9 (standard deviation 21.6, range 0-90) for non-buffered injections

Biohacker Protocol (experimental) Dose: 0.05 0.1 mg (= 24 clicks) Duration: 4 6 weeks Frequency: Daily microdose before rest cycle Cycle Interval: 1 2 weeks off before repeating Goal / Description: Low-dose continuous exploration of sleep quality and recovery markers

Nadeem, M., Rikhari, H

Future studies are needed to further elucidate its direct regulatory effect on novel pyroptotic molecules such as gasdermin E