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Because Glutathione is used up quickly in fighting oxidative stress, chronic illness, or medication use, seniors are particularly likely to benefit from supplementation to restore healthy levels

Abbreviations The following abbreviations are used in this manuscript: BALF Bronchoalveolar Lavage Fluid BW Body Weight CINC Cytokine-induced neutrophil chemoattractant CXCL Chemokine Ligand FTIR Fourier-transform infrared IL Interleukin GPX4 Glutathione peroxidase 4 FTH1 Ferritin heavy chain 1 MNP Micro- and nanoplastic MMP Matrix Metalloproteinase MP Microplastic NLRP3 Nod-like receptor family pyrin domain containing 3 NP Nanoplastic PE Polyethylene PET Polyethylene terephthalate PP Polypropylene PS Polystyrene PVC Polyvinyl Chloride ROS Reactive Oxygen Species TLR Toll Like Receptor TGF Transforming Growth Factor TNF Tumor Necrosis Factor Footnotes Conflicts of Interest: The authors declare no conflicts of interest

In fact, GSNO reductase-dependent oxidation of HMGSH is increased 8-fold in the presence of GSNO in vitro and more than 20-fold in crude lung and liver lysates

Senescent cells, through the secretion of SASP factors into their environment, influence neighboring non-senescent cells and the extracellular matrix (ECM), leading to inflammation, fibrosis, and programmed death of healthy cells, while simultaneously becoming resistant to apoptosis [34]

10.1016/j.nbd.2023.106210 115 YangW