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16 The possibility of these and additional systemic effects warrants large-scale clinical trials to determine a safe and effective dose

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The strategies to address senescent cells and replenish exhausted stem cells during the aging process, as well as supplementing metabolic substances like NAD+, gene therapy, or epigenetic approaches to mitigate aging, are different because they aim to promote the repair of senescent cells rather than inducing their apoptosis (Covarrubias et al., 2020

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The findings differ from prior hypometabolic findings in ME/CFS plasma