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H.BodokyG.et al (2017)

High unconjugated bilirubin may be caused by a spleen disorder or hemolytic anemia

Data availability The data that support the findings of this study are openly available in Protein Data Bank (PDB) at PDB ID: 8PDD, 8PL0, 8PL1, 8PL2, 8PL3, 8PL4, 8PL5, 8PL6, 8PL7, 8PL8, 8PL9, 8PLA, 8PLB, 8PLC, 8PLD, 8PLE, 8PLF, 8PLG, 8PLH, 8PLI, 8PLJ, 8PLK, 8PLL, 8PLM, 8PLN, 8PLO, 8PLP, 8PLQ, 8PLR, 8PLS, 8PLT, 8PLU, 8PLV, 8PLW, 8PLX, 8PLY

available only through 503A compounding pharmacies under physician supervision Typical research dose range / 200-800 mcg/day subcutaneously, cycled 4-8 weeks Known lethal dose (LD50) / Not established in any species studied to date Rodent acute toxicity ceiling / No mortality observed at doses exceeding 10 mg/kg intraperitoneally Most reported excess-dose symptoms / Nausea, lightheadedness, flushing, injection-site irritation Organ toxicity at supratherapeutic doses / Not demonstrated in published preclinical literature Antidote availability / No specific antidote exists

doi: 10.1034/j.1399-3062.4.s3.2.x 164 LortholaryOCharlierCLebeauxDLecuitMConsignyPH

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