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Its anti-tumor activity manifests through various mechanisms, including the induction of direct homotypic aggregation (HA)-related apoptosis, mediated by via actin cytoskeleton polymerization, caspase-dependent pathways, lysosome-associated pathways, and the activation of immune mechanisms [82]

Materials and Methods: Forty male Sprague-Dawley rats weighing between 200 and 250 g were randomized into five different groups ( n = 8 per group)

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Role of pyroptosis in traumatic brain and spinal cord injuries

Specifically, we cloned the Hyg- or Zeo-resistance gene flanked with dif sequences and multiple restriction sites into pUC57, yielding pUC-Hyg or pUC-Zeo, respectively (Fig