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276 In addition, lipid metabolism disorders caused by high lipid levels lead to the dysregulation of GSH and ferroptosis of vascular smooth muscle cells

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Adverse effects occur when ozonation products overwhelm the bodys anti-oxidant system, and can lead to toxicity that includes the formation of free radicals and reactive intermediates, induction of lipid peroxidation chain reaction, destruction of biomolecules and enzymes, and alteration of cellular membranes with tissue destruction [19, 43]

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