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What is increasingly emerging from the literature is that, although it is traditionally considered an extracellular pathogen, the meningococcus engages in complex interactions with host cells in the intracellular microenvironment

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It can therefore be used as a basis for a possible hypothesis of new in vitro studies to compare the different molecules, for new in vivo studies and for the investigation of potential action mechanisms and applications for new drugs to combat diseases of the oral cavity

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Wardman P, Candeias LP

Indeed, control (DMSO), Necrostatin, Z-VAD, or chloroquine failed to inhibit R4VPL3-1-induced cell death