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However, based on pharmacokinetic data, the approximate duration of detectability for a single dose of oxycodone is roughly estimated to be one to two days following drug exposure

But in none of the reported cases in clinical trials did those things require hospitalization or cause necrosis

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And the subjects who got GH were more likely to retain fluid and experience fatigue than were the volunteers who got the placebo

A useful indication of the safety margin available for a drug is given by the therapeutic index (TI): Drugs such as diazepam have a TI of about 50 and it is difficult for even the most inept doctor to cause serious toxicity with diazepam