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However, in the context of hepatic steatosis, a variation in the HSD17B13 gene is linked to a lower risk of inflammation and fibrosis

While the exact connection is not yet fully understood, it suggests that TRPM3 dysfunction may contribute to this common symptom

Emanuele Rinninella, Agostino Gemelli University Polyclinic, Italy Updates Copyright 2017 Khanna, Jaiswal and Gupta

PMID 32678081

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2.2 Transcriptional regulatory networks 2.2.1 Epigenetic dominance of the TOX/NR4A family In the fate determination of exhausted T cells, the transcription factors of the TOX and NR4A families serve as masterminds, reshaping the gene expression profile of T cells through epigenetic regulation, gradually plunging them into the quagmire of exhaustion (112, 113)