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For patients who have not previously been diagnosed with vitamin B12 deficiency or prescribed a vitamin B12 injection, the medicine can be offered if vitamin B12 deficiency is suspected based on signs, symptoms and/or risk factors, though confirmation of vitamin B12 deficiency by a reliable test kit should also be considered

NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism

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X-ray crystallographic studies have demonstrated that copper coordination occurs through the N-terminal amino group of glycine, the deprotonated peptide nitrogen of the Gly-His bond, and the imidazole nitrogen of histidine, forming a square-planar geometry characteristic of Cu(II) complexes

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doi:10.1007/s10541-005-0248-3 13