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At the level of the mitochondrial inner membrane ETC, BDNF upregulates the expression of Nicotinamide adenine dinucleotide (NADH): ubiquinone oxidoreductase core subunit S1 (NDUFS1, a subunit of complex I) and cytochrome C oxidase subunit 5B (COX5B, a subunit of complex IV) via TrkB-mediated phosphorylation of cAMP-response element binding protein (CREB), restoring the activity of mitochondrial complexes I/IV in PD models [94, 95]

ACKNOWLEDGEMENTS The authors gratefully acknowledge the support of Department of Science & Technology and University Grants Commission for their assistance in developing instrumental and laboratory facilities in the department

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The heavy chain 4F2hc is a single transmembrane spanning glycoprotein (also called CD98hc or SLC3A2) 17,18 necessary for correctly trafficking the transporter to the plasma membrane 18,19