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The most significant risk is serotonin syndrome, a potentially fatal condition that can occur if Methylene Blue, a potent MAO-A inhibitor, is combined with SSRI/SNRI antidepressants or other serotonergic substances

But in CNS, where biology depends so heavily on human-specific structure and function, the translation gap remains a serious issue

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doi: 10.1152/ajpcell.00029.2008 187 MorriceJ