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The concept was that poor fetal nutrition would lower fetal IGF-I and program the child to a low IGF-I setpoint and slower postnatal growth, an epigenetic phenomenon that could be preserved over a few generations (45)

534 Mechanistically, metformin enhances autophagy, promoting clearance of immune complexes and dysfunctional organelles, thereby reducing inflammatory burden

If that is well-tolerated (minimal side effects), the dose might be increased to 100 mg per injection in subsequent weeks

Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B12 deficiency: randomised placebo controlled trial

Careful needle handling prevents injury and maintains solution purity

This antioxidant action may help protect the skin from environmental stressors, reducing signs of aging and promoting a healthier glow from within