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4A), while simultaneously downregulating key lipophagy markers (LAMP2 and beclin1) and upregulating SQSTM1/p62 expression, with no significant alteration in LC3A/B ratios (Fig

Should this pharmacological profile be confirmed in late-stage clinical studies, optimized FGF21 analogs have the potential to not only resolve liver pathology, but also to reduce risk of cardiovascular morbidity and mortality, and incidence of organ damage associated with inadequate glycemic control

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In clinical research, intra-articular injection therapy has shown significant efficacy and safety in treating knee OA

This local iron overload in DSCs triggers ferroptosis through reduced GSH and glutathione peroxidase four levels with the concomitant increase in lipid and cellular ROS