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Description

R3 is an amino acid selected from isoleucine, leucine and valine

Generative AI statement The author(s) declare that no Generative AI was used in the creation of this manuscript

We do not prescribe the 25mg formulation as a starting dose without clinical justification

As FOXO4 is a transcription factor, this nuclear localization indicates higher transcriptional regulatory activity, suggesting FOXO4 activity is involved in Leydig cells senescence