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Due to the excessive release of calcium ions in the cytosol, it was depleted from its natural reservoir in the body, like teeth and bone, which finally leads to dental fluorosis, enamel hypo mineralization, weakening tooth structure, and susceptibility to decay

To explore this idea, we bred the MMTV-PyMT transgenic mouse strain (which spontaneously develops breast tumours) 26 with an uninduced Gclc f/f Rosa26 creERT2 mouse 27 in which the rate-limiting step in GSH synthesis, the glutamatecysteine ligase catalytic subunit (GCLC), can be knocked out throughout the body after induction with tamoxifen

Therapeutic archive

Mohan R , Selvakumar A S, S R, K M, S S, Kathiah R, T R, Rajan Prasaad P, Kumar S D, K S

Tinggi U (2008) Selenium: its role as antioxidant in human health

The membrane was then washed again three times, and the protein bands visualized using Bio-Rad Clarity Western Enhanced Chemiluminescence substrate on a Bio-Rad Chemidoc Imaging System