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Current pharmacologic strategies, which include NSAIDs, corticosteroids, and opioids, carry limitations including gastrointestinal toxicity, impaired bone healing, and dependency risk (Zhao-Fleming et al

10.3390/biomedicines12040814 79 LiH.LiangH.WeiL.ShiD.SuX.LiF.et al (2022a)

Encapsulation efficiency improved substantially, enabling extended experimental timelines

A marked secondary effect of NA treatment is that it prompts a severe flushing reaction in patients

In addition, tissue taurine depletion increases UPR, which may be connected with an enhancement in protein folding by taurine [57]

High-risk patients including those on long-term or high-dose metformin, older adults, and those with additional risk factors should be considered for periodic B12 monitoring