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Curr Opin Gastroenterol 2012;28:1518

It's estimated that almost 40% of the US population is B12 deficient, ranging from mild deficiencies that can cause weakness, tiredness, mood changes and neurological problems, to significant deficiencies that are associated with anemia, easy bruising, numbness in the fingers and toes, difficult walking, depression, memory loss and dementia

Individual results vary and therapies may be investigational or used off-label

Jacqueline Wolf, associate professor of medicine at Harvard Medical School