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Gugan P

Diabetes patients face particular vulnerability due to metformin therapy, which significantly impairs B12 absorption over time

Moreover, pretreatment on the petiole of the wounded leaf with LaCl 3 severely reduced the GSH-inducible expression of defense genes in systemic leaves (Fig

This has been explored by clinical trials, the most notable of which was METAOD005

These immunogenic properties are particularly significant in glioblastoma, where ferroptosis-related gene signatures demonstrate strong predictive value for response to PD-1 blockade in recurrent tumors, suggesting an intrinsic synergy between ferroptosis and immune checkpoint inhibition [129]

Microenvironmental influences on T cell immunity in cancer and inflammation