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Further studies documented that NTBC was a potent inhibitor of 4-hydroxyphenylpyruvate dioxygenase (HPD), which catalyzes conversion of 4-hydroxyphenylpyruvate to homogentisic acid 53 (Figure 1)

She later developed a passion for immunology by conducting research on type I diabetes during a summer internship at the Harvard Medical School affiliate Joslin Diabetes Center

Metabolic effects of nicotinamide administration in rats

Control of p53 and NF-B signaling by WIP1 and MIF: role in cellular senescence and organismal aging

Current Western medical treatment is based on disease-modifying anti-rheumatic drugs (DMARDs) (4), but there are problems such as insufficient efficacy, drug resistance and adverse reactions, and the clinical outcomes of RA patients are not satisfactory (3)

Prescribers refer to it as the drug of last resort