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In ovarian granulosa cells, hypermethylation of the steroidogenic enzyme cytochrome P450 family 19 subfamily A member 1 (CYP19A1) promoter reduces estrogen biosynthesis while relatively increasing androgen production, thereby exacerbating hyperandrogenemia (52)

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doi: 10.1016/j.redox.2020.101507 18 HarveyIBoudreauAStephensJM

J Med Chem 51:66426645 Tsiakitzis K, Papagiouvannis G, Theodosis-Nobelos P, Tziona P, Kourounakis PN, Rekka EA (2017) Synthesis, antioxidant and anti-inflammatoy effects of antioxidant acid amides with GABA and N-Acyl-pyrrolidin-2-ones