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Sustained elevation of IGF-1 is associated, in observational studies of acromegaly (a disease of GH excess), with increased risk of several cancers including colorectal and breast

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The activated Ras stimulates Raf kinase to phosphorylate and activate MAP kinase kinase (MEK), which, in turn, activates ERK1/2 (MAPK1/2) via serine/threonine phosphorylations of the latter proteins